HGS (gene)
Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.[1][2][3]
Interactions
HGS (gene) has been shown to interact with TSG101,[4][5] STAM2,[4][6] Merlin,[7][8] DLG4,[9] IL2RB,[10] EPS15,[6][11] CLTC[12] and Signal transducing adaptor molecule.[1][4][6]
References
- ^ a b Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (Jan 1998). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J Biol Chem 272 (52): 32785–91. doi:10.1074/jbc.272.52.32785. PMID 9407053.
- ^ Lu L, Komada M, Kitamura N (Aug 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.
- ^ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9146.
- ^ a b c Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ Lu, Quan; Hope Lila Weiqiao, Brasch Michael, Reinhard Christoph, Cohen Stanley N (Jun. 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (13): 7626–31. doi:10.1073/pnas.0932599100. ISSN 0027-8424. PMC 164637. PMID 12802020. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164637.
- ^ a b c Bache, Kristi G; Raiborg Camilla, Mehlum Anja, Stenmark Harald (Apr. 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. (United States) 278 (14): 12513–21. doi:10.1074/jbc.M210843200. ISSN 0021-9258. PMID 12551915.
- ^ Gutmann, D H; Haipek C A, Burke S P, Sun C X, Scoles D R, Pulst S M (Apr. 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. (England) 10 (8): 825–34. doi:10.1093/hmg/10.8.825. ISSN 0964-6906. PMID 11285248.
- ^ Scoles, D R; Huynh D P, Chen M S, Burke S P, Gutmann D H, Pulst S M (Jul. 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. (ENGLAND) 9 (11): 1567–74. doi:10.1093/hmg/9.11.1567. ISSN 0964-6906. PMID 10861283.
- ^ Chetkovich, Dane M; Bunn Robert C, Kuo Sheng-Han, Kawasaki Yoshimi, Kohwi Minoree, Bredt David S (Aug. 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. (United States) 22 (15): 6415–25. PMID 12151521.
- ^ Yamashita, Yuki; Kojima Katsuhiko, Tsukahara Tomonori, Agawa Hideyuki, Yamada Koichiro, Amano Yuji, Kurotori Naoki, Tanaka Nobuyuki, Sugamura Kazuo, Takeshita Toshikazu (May. 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell. Sci. (England) 121 (Pt 10): 1727–38. doi:10.1242/jcs.024455. ISSN 0021-9533. PMID 18445679.
- ^ Bean, A J; Davanger S, Chou M F, Gerhardt B, Tsujimoto S, Chang Y (May. 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. (UNITED STATES) 275 (20): 15271–8. doi:10.1074/jbc.275.20.15271. ISSN 0021-9258. PMID 10809762.
- ^ Raiborg, C; Bache K G, Mehlum A, Stang E, Stenmark H (Sep. 2001). "Hrs recruits clathrin to early endosomes". EMBO J. (England) 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125612.
Further reading
- Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS 65: 131–65. PMID 8380735.
- Komada M, Masaki R, Yamamoto A, Kitamura N (1997). "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes". J. Biol. Chem. 272 (33): 20538–44. doi:10.1074/jbc.272.33.20538. PMID 9252367.
- Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
- Bean AJ, Davanger S, Chou MF et al. (2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi:10.1074/jbc.275.20.15271. PMID 10809762.
- Kwong J, Roundabush FL, Hutton Moore P et al. (2000). "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis". J. Cell. Sci. 113 ( Pt 12): 2273–84. PMID 10825299.
- Scoles DR, Huynh DP, Chen MS et al. (2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. doi:10.1093/hmg/9.11.1567. PMID 10861283.
- Gillooly DJ, Morrow IC, Lindsay M et al. (2000). "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". EMBO J. 19 (17): 4577–88. doi:10.1093/emboj/19.17.4577. PMC 302054. PMID 10970851. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=302054.
- Miura S, Takeshita T, Asao H et al. (2001). "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA". Mol. Cell. Biol. 20 (24): 9346–55. doi:10.1128/MCB.20.24.9346-9355.2000. PMC 102191. PMID 11094085. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102191.
- Chin LS, Raynor MC, Wei X et al. (2001). "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor". J. Biol. Chem. 276 (10): 7069–78. doi:10.1074/jbc.M004129200. PMID 11110793.
- Gutmann DH, Haipek CA, Burke SP et al. (2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. doi:10.1093/hmg/10.8.825. PMID 11285248.
- Sasaki Y, Sugamura K (2001). "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1". J. Biol. Chem. 276 (32): 29943–52. doi:10.1074/jbc.M104230200. PMID 11397816.
- Raiborg C, Bremnes B, Mehlum A et al. (2001). "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes". J. Cell. Sci. 114 (Pt 12): 2255–63. PMID 11493665.
- Raiborg C, Bache KG, Mehlum A et al. (2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMC 125612. PMID 11532964. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125612.
- Steen H, Kuster B, Fernandez M et al. (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". J. Biol. Chem. 277 (2): 1031–9. doi:10.1074/jbc.M109992200. PMID 11687594.
- Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMC 2173266. PMID 11916981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173266.
- Tchernev VT, Mansfield TA, Giot L et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. PMC 2039936. PMID 11984006. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2039936.
- Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking". J. Biol. Chem. 277 (31): 28212–21. doi:10.1074/jbc.M111612200. PMID 12021262.